Ultrasound Guided vs Unguided Intra-articular Knee Injections


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 13-008328
    Sponsor Protocol Number: 13-008328

About this study

To determine the accuracy of unguided versus ultrasound (US) guided knee joint injections in obese patients with no clinically detectable effusion.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria

  • BMI > 30
  • No clinically detectable knee effusion
  • Clinical or radiographic evidence of knee osteoarthritis or inflammatory arthritis
  • Must be referred to the Pain Clinic for treatment

Exclusion Criteria

  • History of surgery on the affected knee
  • Evidence of untreated systemic infection or systemic immunocompromise
  • Evidence of cutaneous infections near the study knee injection site
  • Patients on warfarin with an INR > 3.0
  • Patients on oral antiplatelet or anticoagulant medications will be excluded if they have documented evidence of renal insufficiency (GFR < 60)
  • History of iodinated contrast allergy or significant reaction to corticosteroids or lidocaine

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Matthew Pingree, M.D.

Closed for enrollment


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