Sex Steroid Metabolism and Aging

Normal reproductive function requires a highly coordinated and complex interplay of events in the hypothalamic-pituitary-ovarian axis, and important changes occur with menopause and aging.

Today, the evaluation of the neuroendocrine axis in women is providing important clues into the nature of aging.

Areas of focus

Related to sex steroid metabolism and aging, research in the Women's Health Research Center is focusing on:

  • Estrogen stimulation of growth hormone and insulin-like growth factor-1 secretion in postmenopausal women
  • Estrogen signaling in health and disease
  • Sex differences in cellular senescence
  • Effects of declining sex steroid levels on bone and aging

Faculty involved

Center faculty involved in sex steroid metabolism and aging research include: