There are important differences in bone formation, remodeling and fracture risk between men and women. Women begin with lower bone density than men, and they lose bone mass at a faster rate than men as they age.
Eighty percent of people affected by osteoporosis are women, and 40 percent of women in the U.S. will experience at least one fragility-related fracture during their lives. In aging women, osteoporosis is the leading cause of disability and a major cause of morbidity and mortality.
Areas of focus
Osteoporosis-related focus areas in the Women's Health Research Center include:
- Molecular basis of bone remodeling defects
- Effects of estrogen on gene expression related to bone matrix proteins, growth factors, cytokines and estrogen signaling
Center faculty members involved in osteoporosis research include: