Cynthia H. McCollough, Ph.D.
Although state-of-the-art CT imaging provides accurate submillimeter details of the size and location of renal stones, current routine clinical image analysis does not differentiate stone composition. Dual energy CT technique, which is based on the difference in X-ray attenuation properties between stones of differing chemical compositions, has been shown to accurately differentiate between uric acid and non-uric acid urinary stones.
The purpose of the Imaging Core is to provide dual energy CT data acquisition and analyses in support of the O'Brien Urology Research Center. These functions directly support the Noninvasive Characterization of Renal Stones Project, the CT and Urinary Correlates of Renal Stone Precursor Lesions Project, and the Epidemiology of Nephrolithiasis and Chronic Kidney Disease Project, and may also be of value for future pilot projects.
Services provided by the Imaging Core include:
- Dual energy CT scanning of ex-vivo specimens or of patients
- Dual energy material decomposition analysis to determine stone type
- High-resolution image reconstruction and analysis to determine stone volume
- Coordination of micro-CT scanning and data analysis with James C. Williams Jr., Ph.D., of Indiana University-Purdue University Indianapolis