• How an artificial pancreas functions

    How an artificial pancreas functions

  • Artificial pancreas worn by patient

    Artificial pancreas worn by patient

  • Physical Activity Monitoring System

    Physical Activity Monitoring System

  • Islet cluster from pluripotent stem cells

    Islet cluster from pluripotent stem cells

  • DNA sequence analysis readout

    DNA sequence analysis readout

  • Immunofluorescence images of fat cells

    Immunofluorescence images of fat cells

Due to high prevalence, economic impact and potential for creating human suffering, the Mayo Clinic Diabetes Research Center places special emphasis on research that establishes cause, optimizes treatment, and develops methods to prevent diabetes and obesity.

The research domains (Discover, Translate, and Apply) and their related cores: 1) discover new metabolomic and genomic science related to diabetes mellitus, metabolism, and obesity; 2) translate that science by understanding its biologic expression in animals and humans; and 3) apply newly discovered biology to the understanding of clinical diabetes in humans by testing the effects of intervention with pharmacologic and technologic therapies.

Our Diabetes Research Center is anchored in translational research and facilitates the application of scientific discoveries for the ultimate purpose of preventing, treating and curing diabetes mellitus in humans. The Center is structured to promote interactions among investigators, collaboration between disciplines, and share resources among all participants — individuals, departments and institutions.

The Mayo Clinic Diabetes Research Center is a multi-site, multi-institutional entity with membership at Mayo Clinic in Rochester, Minn., Jacksonville, Fla. and Phoeniz, Ariz.; and Arizona State University in Tempe, Ariz.

The Center is comprised of an Administrative Core, Enrichment Core, and a Pilot and Feasibility Program; in addition to seven scientific cores residing in three different conceptual domains:

  • Discover domain contains i) Genomic and ii) Mass Spectrometry, Metabolomic, Mitochondrial Biology Cores
  • Translate domain contains i) Autonomic and Neurovascular Core, ii) a Tracer Methodology/Human Phenotyping Core, and iii) Animal Phenotyping and Procedures Core
  • Apply domain contains i) Clinical Trials Core and ii) Biostatistics and Data Management Core.

The Enrichment and Training Program trains, links, and cultivates the research careers of new and newly engaged investigators by establishing an intellectual-sharing environment through seminars, mini sabbatical programs, visiting scholars lectures and a newsletter.

The Pilot and Feasibility Program is an integral part of the Center.This program has the dual goal of expanding the research base of established investigators and funding new investigators.

The Administrative Core interacts with the leadership of Mayo Clinic to align clinical translation with cutting-edge research and consists of:

  • Executive Committee — enhances community and research volunteer engagement.
  • Internal Advisory Board — leads Mayo Clinic scientists and serves as a liaison between the Center and the institutional leadership to ensure interdisciplinary collaboration and expeditious implementation of advances in technology and therapeutics.
  • External Advisory Committee — leads scientists who guide the group in developing research strategy, setting research priorities, interacting with other diabetes research centers and industry, and engaging with the general community to ensure that advances in research make a difference to patient's lives.


Tracing our history in diabetes care and research, Mayo Clinic:

  • Has a 100 plus-year history of delivering world-class care for patients from all over the world; and a background in diabetes research that can be traced to 1919.
  • Was a pioneer in developing intensive insulin therapy in the 1970's following pioneering studies of glucose variability in various types of diabetes starting in the 1950's.
  • Recruited the largest number of subjects to the landmark Diabetes Control and Complications Trial.
  • Is an integral part of the NIH Artificial Pancreas Project, serving as the Innovative Physiology Center for personalized closed-loop therapy for type 1-diabetes.