- Dennis Wigle, M.D., Ph.D.
- Regenerative Medicine Biotrust
Dennis Wigle, M.D., Ph.D.: So our goal in designing the biotrust is to really set up that infrastructure so that we can use it both for research purposes and for the real clinical translation for real patient care purposes and have that infrastructure to be able to use for regenerative medicine purposes.
The biotrust is basically the infrastructure, or the set of building blocks, that we think here at Mayo Clinic is going to be required in order to be able to really translate regenerative medicine technologies to patient care. So, for example, the capability to be able to store various live cell types, to be able to reprogram cell types, to be able to grow large numbers of cells that we might need or want to use for clinical applications requires a very specialized infrastructure to be able to do that, that goes beyond just the regular biospecimen banking or normal cell or tissue banking that we think of presently.
So I see the biotrust really performing a key function of both the investigative and the clinical side as we really move forward to understanding how to use these technologies for patient care.
The Center for Regenerative Medicine has a growing number of shared services that support its scientific focus areas and the wider Mayo Clinic community.
These shared services accelerate progress within the center and make it possible to carry out complex tasks, such as cell manufacturing, entirely in-house.
Human Cellular Therapy Laboratory
The Center for Regenerative Medicine works with the Human Cellular Therapy Laboratory to develop and produce safe cellular products for research and patient care purposes.
Regenerative Medicine Biotrust
The Regenerative Medicine Biotrust enables the Center for Regenerative Medicine to collect, process and store cells and other biospecimens from individual patients.
Calcium Signaling Laboratory
The Calcium Signaling Laboratory focuses on two calcium regulatory systems, plasma membrane calcium pumps and calmodulin-like protein and its targets. A broad range of techniques are used in the lab to support the Center for Regenerative Medicine, including those related to molecular biology, protein biochemistry and cell biology.