Lymphoma SPORE Core Resources

The University of Iowa/Mayo Clinic Lymphoma SPORE Grant has three scientific core resources and an administrative core, all of which help consolidate and facilitate the expertise required for effective lymphoma research.

The four cores in the Lymphoma SPORE are:

Core 1. Administrative Core

The Administrative Core provides an organizational structure to support collaboration, a system for financial management, and formal procedures for systematic review of research projects and project growth and development.

Specifically, the Administrative Core:

  • Provides leadership, organizational support and financial management for Lymphoma SPORE investigators
  • Coordinates communication and collaboration between the University of Iowa and Mayo Clinic
  • Provides information transfer to the scientific community and the public
  • Provides leadership and organizational support for internal and external review for SPORE research projects
  • Works closely with SPORE patient advocates about research progress and input
  • Fosters trainee development

Core 2. Biospecimens Core

  • Director: Ahmet Dogan, M.D., Ph.D.
  • Co-director: Sergei Syrbu, M.D., Ph.D., University of Iowa

The Biospecimens Core provides a coordinated, centralized and dedicated core for the procurement, processing and annotation of biospecimens from patients with lymphoma, including chronic lymphocytic leukemia and small lymphocytic lymphoma.

The goal of the Biospecimens Core is to procure a variety of specimens from all patients involved in Lymphoma SPORE protocols and all newly diagnosed lymphoma patients seen at the University of Iowa or Mayo Clinic in Rochester, Minn., who are enrolled in certain SPORE studies.

Specifically, the Biospecimens Core:

  • Provides accurate classification of all lymphomas from patients enrolled in Lymphoma SPORE protocols
  • Collects, processes, banks and distributes biologic specimens from University of Iowa and Mayo Clinic lymphoma patients for translational research
  • Tracks all biospecimens and ensures linkage to clinical and outcomes data and other related data
  • Serves as a resource of expertise, collaborative support and service for projects. Services include: Pathology review and classification, specimen review, immunohistochemistry, flow cytometry, in situ hybridization, fluorescence in situ hybridization, cytogenetics, laser capture microdissection, tissue arrays, gene expression profiling analyses, and digital image analysis

Core 3. Biostatistics and Bioinformatics Core

  • Director: Brian J. Smith, Ph.D., University of Iowa
  • Co-directors: Susan L. Slager, Ph.D.; Terry Braun, Ph.D., University of Iowa

The Biostatistics and Bioinformatics Core provides statistical collaboration, data management, bioinformatics and computational biology research support for Lymphoma SPORE projects, programs and cores.

Specifically, the Biostatistics and Bioinformatics Core:

  • Provides statistical and bioinformatics support across different fields, including epidemiological studies, basic sciences including translational and immunologic correlative studies, gene microarray and gene and mutation discovery, expression analysis and genomics, and information management
  • Provides a mechanism for the management and integration of existing and newly collected data through consistent and compatible data handling. Areas of support include database development, data form development and processing, data collection and entry, data archiving, quality control, and management of information related to gene mutation identification and genotyping data for disease linkage experiments.
  • Provides bioinformatics support, including analysis of exome-sequencing results for identification of pathogenic changes and integration with data from other public genome and cancer resources

Core 4. Clinical Research Core

The Clinical Research Core provides centralized, coordinated support for clinical research performed as part of the translational research studies of the Lymphoma SPORE. It is composed of the Clinical Trials Unit and the Molecular Epidemiology Resource.

Specifically, the Clinical Research Core:

  • Coordinates and performs Lymphoma SPORE clinical trials protocols, including developing clinical trials, assisting in patient accrual, managing protocol amendments and providing quality control of data
  • Coordinates observational epidemiology protocols and partners with the Molecular Epidemiology Resource on population science research in lymphoma to obtain consent from newly diagnosed lymphoma patients and to abstract and enter clinical and epidemiologic data