Focus Areas

The Gastrointestinal Cancer Program focuses on two research themes:

  • Mechanisms of carcinogenesis and tumor biology
  • Early detection and prevention

The program also has a Specialized Program of Research Excellence (SPORE) grant for pancreatic cancer.

Research Area Laboratories Faculty

Mechanisms of carcinogenesis and tumor biology

This group of investigators works to identify and define the molecular mechanisms that support neoplastic transformation of both luminal and solid organs of the gastrointestinal tract. They place special emphasis on:

  • Receptor signaling cascades
  • Cell death pathways
  • Checkpoint control
  • Epigenetic transcriptional regulation

Early detection and prevention

The mission of this group of investigators is twofold:

  • Identifying patient subgroups, including people at high risk, which may facilitate the development of novel screening tools and early detection strategies for gastrointestinal cancers.
  • Coordinating clinical databases, specimen collection and laboratory activities that support the development of interventions to reduce the incidence and improve the survival of patients at risk of or diagnosed with gastrointestinal cancers.