The Advanced Genomics Technology Center (AGTC) brings together seven different genomics-oriented shared resources to facilitate interactions with the Mayo research staff and to increase the coordination and efficiency of our activities. With the support and cooperation of the Genomics Research Center, the comprehensive Cancer Center, and the General Clinical Research Center, the facilities of the AGTC are working to provide professional, efficient, and low-cost access to the latest genomics technologies to all Mayo investigators.

The AGTC also operates laboratory-based training programs in basic molecular biology and tissue culture techniques. Together, these facilities occupy about 20,000 sq. ft. of laboratory space on the tenth floor of the Guggenheim research building. The directors of the seven facilities meet on a regular basis to improve coordination and workflow, and to discuss opportunities for improving our services for the community.

The seven resources included in the AGTC are:

  • Biospecimens Accessioning and Processing (BAP)
    Specimen handling, processing, and preservation plus nucleic acid extraction
  • Cytogenetics
    Routine cytogenetics plus SKY, FISH and CGH analysis
  • DNA Sequencing
    Full service automated DNA sequence analysis
  • DNA Synthesis
    Custom synthesis of oligonucleotide probes, primers, RNAs and molecular beacons
  • Genotyping
    Linkage analysis (microsatellites), SNP analysis, genome-wide screens
  • Microarray
    Transcriptional profiling using Affymetrix microarrays and custom spotted arrays
  • Tissue and Cell Molecular Analysis (TACMA)
    Immunohistochemistry, in situ hybridization, digital image analysis, and laser capture microdissection