Publications

  1. Kaiser RA, Carlson DF, Allen KL, Webster DA, VanLith CJ, Nicolas CT, Hillin LG, Yu Y, Kaiser CW, Wahoff WR, Hickey RD, Watson AL, Winn SR, Thony B, Kern DR, Harding CO, Lillegard JB. Development of a porcine model of phenylketonuria with a humanized R408W mutation for gene editing. PLoS One. 2021; 16 (1):e0245831 Epub 2021 Jan 25
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  2. Nicolas CT, Kaiser RA, Hickey RD, Allen KL, Du Z, VanLith CJ, Guthman RM, Amiot B, Suksanpaisan L, Han B, Francipane MG, Cheikhi A, Jiang H, Bansal A, Pandey MK, Garg I, Lowe V, Bhagwate A, O'Brien D, Kocher JA, DeGrado TR, Nyberg SL, Lagasse E, Lillegard JB. Ex Vivo Cell Therapy by Ectopic Hepatocyte Transplantation Treats the Porcine Tyrosinemia Model of Acute Liver Failure. Mol Ther Methods Clin Dev. 2020 Sep 11; 18:738-750 Epub 2020 July 10
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  3. Thompson WS, Mondal G, Vanlith CJ, Kaiser RA, Lillegard JB. The future of gene-targeted therapy for hereditary tyrosinemia type 1 as a lead indication among the inborn errors of metabolism. Expert Opin Orphan Drugs. 2020; 8 (7):245-256 Epub 2020 July 21
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  4. Eyerly-Webb SA, Joshi S, Dion E, Snowise S, Lillegard J, Feltis BA. Fetal Non-Ovarian Abdominopelvic Cystic Lesions: A Single-Center Report. Fetal Diagn Ther. 2020; 47 (12):955-959 Epub 2020 Oct 13
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  5. Eyerly-Webb S, Nicolas CT, Watson D, Dion E, Amin R, Wagner AJ, Lampland A, Wagner AJ, Bendel-Stenzel E, Macardle CA, Kunisaki SM, Jorgenson A, Lillegard J, Feltis B, Lillegard J. Dynamic discriminant model for predicting respiratory distress at birth based on mass volume ratio in fetuses with congenital lung malformation. Ultrasound Obstet Gynecol. 2019 Dec; 54 (6):759-766 Epub 2019 Nov 12
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  6. Kaiser RA, Nicolas CT, Allen KL, Chilton JA, Du Z, Hickey RD, Lillegard JB. Hepatotoxicity and Toxicology of In Vivo Lentiviral Vector Administration in Healthy and Liver-Injury Mouse Models. Hum Gene Ther Clin Dev. 2019 Jun; 30 (2):57-66 Epub 2019 Apr 11
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  7. Goodnight WH, Bahtiyar O, Bennett KA, Emery SP, Lillegard JB, Fisher A, Goldstein R, Jatres J, Lim FY, McCullough L, Moehrlen U, Moldenhauer JS, Moon-Grady AJ, Ruano R, Skupski DW, Thom E, Treadwell MC, Tsao K, Wagner AJ, Waqar LN, Zaretsky M, fMMC Consortium sponsored by NAFTNet. Subsequent pregnancy outcomes after open maternal-fetal surgery for myelomeningocele. Am J Obstet Gynecol. 2019 May; 220 (5):494.e1-494.e7 Epub 2019 Mar 15
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  8. VanLith CJ, Guthman RM, Nicolas CT, Allen KL, Liu Y, Chilton JA, Tritz ZP, Nyberg SL, Kaiser RA, Lillegard JB, Hickey RD. Ex Vivo Hepatocyte Reprograming Promotes Homology-Directed DNA Repair to Correct Metabolic Disease in Mice After Transplantation. Hepatol Commun. 2019 Apr; 3 (4):558-573 Epub 2019 Feb 15
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  9. Nicolas CT, Lynch-Salamon D, Bendel-Stenzel E, Tibesar R, Luks F, Eyerly-Webb S, Lillegard JB. Fetoscopy-Assisted Percutaneous Decompression of the Distal Trachea and Lungs Reverses Hydrops Fetalis and Fetal Distress in a Fetus with Laryngeal Atresia. Fetal Diagn Ther. 2019; 46 (1):75-80 Epub 2019 June 25
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  10. Hickey RD, Nicolas CT, Allen K, Mao S, Elgilani F, Glorioso J, Amiot B, VanLith C, Guthman R, Du Z, Chen H, Harding CO, Kaiser RA, Nyberg SL, Lillegard JB. Autologous Gene and Cell Therapy Provides Safe and Long-Term Curative Therapy in A Large Pig Model of Hereditary Tyrosinemia Type 1. Cell Transplant. 2019 Jan; 28 (1):79-88 Epub 2018 Nov 26
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  11. Kaiser RA, Mao SA, Glorioso J, Amiot B, Nicolas CT, Allen KL, Du Z, VanLith CJ, Hickey RD, Nyberg SL, Lillegard JB. Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine. J Vis Exp. 2018 Nov 4; (141) Epub 2018 Nov 04
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  12. VanLith C, Guthman R, Nicolas CT, Allen K, Du Z, Joo DJ, Nyberg SL, Lillegard JB, Hickey RD. Curative Ex Vivo Hepatocyte-Directed Gene Editing in a Mouse Model of Hereditary Tyrosinemia Type 1. Hum Gene Ther. 2018 Nov; 29 (11):1315-1326 Epub 2018 June 22
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  13. Nicolas CT, Hickey RD, Allen KL, Du Z, Guthman RM, Kaiser RA, Amiot B, Bansal A, Pandey MK, Suksanpaisan L, DeGrado TR, Nyberg SL, Lillegard JB. Hepatocyte spheroids as an alternative to single cells for transplantation after ex vivo gene therapy in mice and pig models. Surgery. 2018 Sep; 164 (3):473-481 Epub 2018 June 06
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  14. Elgilani F, Mao SA, Glorioso JM, Yin M, Iankov ID, Singh A, Amiot B, Rinaldo P, Marler RJ, Ehman RL, Grompe M, Lillegard JB, Hickey RD, Nyberg SL. Chronic Phenotype Characterization of a Large-Animal Model of Hereditary Tyrosinemia Type 1. Am J Pathol. 2017 Jan; 187 (1):33-41 Epub 2016 Nov 14
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  15. Hickey RD, Mao SA, Glorioso J, Elgilani F, Amiot B, Chen H, Rinaldo P, Marler R, Jiang H, DeGrado TR, Suksanpaisan L, O'Connor MK, Freeman BL, Ibrahim SH, Peng KW, Harding CO, Ho CS, Grompe M, Ikeda Y, Lillegard JB, Russell SJ, Nyberg SL. Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1. Sci Transl Med. 2016 Jul 27; 8 (349):349ra99
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  16. Hickey RD, Mao SA, Glorioso J, Lillegard JB, Fisher JE, Amiot B, Rinaldo P, Harding CO, Marler R, Finegold MJ, Grompe M, Nyberg SL. Fumarylacetoacetate hydrolase deficient pigs are a novel large animal model of metabolic liver disease. Stem Cell Res. 2014 Jul; 13 (1):144-53 Epub 2014 May 14
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  17. Lillegard JB, Kennedy RD, Ishitani MB, Zarroug AE, Feltis B. Autologous blood patch for persistent air leak in children. J Pediatr Surg. 2013 Sep; 48 (9):1862-6
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  18. Fisher JE, Lillegard JB, McKenzie TJ, Rodysill BR, Wettstein PJ, Nyberg SL. In utero transplanted human hepatocytes allow postnatal engraftment of human hepatocytes in pigs. Liver Transpl. 2013 Mar; 19 (3):328-35
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  19. Fisher JE, McKenzie TJ, Lillegard JB, Yu Y, Juskewitch JE, Nedredal GI, Brunn GJ, Yi ES, Malhi H, Smyrk TC, Nyberg SL. Role of Kupffer cells and toll-like receptor 4 in acetaminophen-induced acute liver failure. J Surg Res. 2013 Mar; 180 (1):147-55 Epub 2012 Dec 20
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  20. Puig CA, Lillegard JB, Fisher JE, Schiller HJ. Hernia of cecum and ascending colon through the foramen of Winslow. Int J Surg Case Rep. 2013; 4 (10):879-81 Epub 2013 Aug 03
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  21. Yu Y, Fisher JE, Lillegard JB, Rodysill B, Amiot B, Nyberg SL. Cell therapies for liver diseases. Liver Transpl. 2012 Jan; 18 (1):9-21
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  22. Lillegard JB, Fisher JE, Nedredal G, Luebke-Wheeler J, Bao J, Wang W, Amoit B, Nyberg SL. Normal atmospheric oxygen tension and the use of antioxidants improve hepatocyte spheroid viability and function. J Cell Physiol. 2011 Nov; 226 (11):2987-96
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  23. Nedredal GI, Yin M, McKenzie T, Lillegard J, Luebke-Wheeler J, Talwalkar J, Ehman R, Nyberg SL. Portal hypertension correlates with splenic stiffness as measured with MR elastography. J Magn Reson Imaging. 2011 Jul; 34 (1):79-87 Epub 2011 May 23
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  24. Lillegard JB, Porterfield JR Jr. Ephedra-Induced Gastric Mucosal Injury. Case Rep Gastroenterol. 2010 Feb 27; 4 (1):79-83
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  25. Lillegard JB, Hanna AM, McKenzie TJ, Moir CR, Ishitani MB, Nagorney DM. A single-institution review of portosystemic shunts in children: an ongoing discussion. HPB Surg. 2010; 2010:964597 Epub 2010 May 06
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  26. Nedredal GI, Amiot BP, Nyberg P, Luebke-Wheeler J, Lillegard JB, McKenzie TJ, Nyberg SL. Optimization of mass transfer for toxin removal and immunoprotection of hepatocytes in a bioartificial liver. Biotechnol Bioeng. 2009 Dec 1; 104 (5):995-1003
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  27. McKenzie TJ, Lillegard JB, Young WF Jr, Thompson GB. Aldosteronomas--state of the art. Surg Clin North Am. 2009 Oct; 89: (5)1241-53.
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  28. Lillegard JB, Sim RB, Thorkildson P, Gates MA, Kozel TR. Recognition of Candida albicans by mannan-binding lectin in vitro and in vivo. J Infect Dis. 2006 Jun 01; 193 (11):1589-97 Epub 2006 Apr 25
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