Search Results 21-30 of 116 for brca1%20and%20brca2%20genes%20and%20breast%20cancer
Also, if you have a family history of genes that increase the risk of breast cancer (BRCA1 or BRCA2) or a very strong family history of breast cancer, your risk of prostate cancer may be higher.
Variants of uncertain significance in the BRCA1 and BRCA2 breast and ovarian cancer genes.
Personalized management of breast, ovarian and endometrial cancer in the presence of strong family history of cancer or germline mutations in cancer predisposition genes such as BRCA1, BRCA2, PALB2, ATM, CHEK2, RAD51C, RAD51D, MLH1, ...
This analysis identified single nucleotide polymorphisms in ZNF423, a previously unrecognized regulator of BRCA1 expression, as a critical determinant of selective estrogen receptor modulator efficacy in the adjuvant setting.
Patients with tumors that have ATM, BRCA1 and/or BRCA2 mutations/deletions/loss of heterozygosity will be randomized in a 1:1:1 fashion to each arm.
The most well-known gene mutations are referred to as BRCA1 and BRCA2.
For many years, it has been understood that the BRCA1 and BRCA2 genes contribute to the etiology of breast cancer.
The list of genetic-associated conditions included: Familial pancreatic cancer Peutz-Jeghers syndrome Hereditary pancreatitis (HP or PRSS mutations) Hereditary colon cancer (Lynch syndrome or mismatch repair mutations MLH1, MSH2, MSH6 and PMS2) Seven...
In the case of PARP inhibitors, work from the Kaufmann laboratory has shown that these agents selectively kill BRCA1- and BRCA2-deficient cells by enhancing activation of an error-prone DNA repair pathway (the nonhomologous end-joini...
These four protein kinases, with the help of mediator proteins, phosphorylate a number of downstream effector proteins, including tumor suppressors p53 and BRCA1.