Mayo Imaging Classification for patients with autosomal dominant polycystic kidney disease
The Mayo Image Classification subclassifies patients with Class 1 autosomal dominant polycystic kidney disease according to age-adjusted, height-adjusted total kidney volume. Classification categories are defined based on estimated annual kidney growth rates of less than or equal to 1.5%, 1.5% to 3%, 3% to 4.5%, 4.5% to 6% and greater than 6%.
Predictive models and imaging biomarkers in autosomal dominant polycystic kidney disease
The lab's research focuses on developing and refining imaging- and biomarker-based approaches to improve risk stratification and predict disease progression in autosomal dominant polycystic kidney disease. Dr. Irazabal developed the Mayo Image Classification for autosomal dominant polycystic kidney disease. This classification system is now widely used nationally and internationally for clinical trial design and risk stratification in patients with autosomal dominant polycystic kidney disease.
Research continues to evaluate advanced imaging techniques and novel biomarkers. The goal is to improve early assessment of disease progression and therapeutic response.
Areas of ongoing investigation include:
- Novel imaging biomarkers.
- Noninvasive assessment of kidney parenchyma.
- Imaging approaches to characterize renal microvascular abnormalities.
- Integration of imaging with vascular and metabolic biomarkers.
- Longitudinal disease modeling and progression prediction.
Related publication
- Irazabal MV, Rangel LJ, Bergstralh EJ, Osborn SL, Harmon AJ, Sundsbak JL, Bae KT, Chapman AB, Grantham JJ, Mrug M, Hogan MC, El-Zoghby ZM, Harris PC, Erickson BJ, King BF, Torres VE; CRISP Investigators. "Imaging Classification of Autosomal Dominant Polycystic Kidney Disease: A Simple Model for Selecting Patients for Clinical Trials." Journal of the American Society of Nephrology. 2015.