About the Lab

Led by Dennis Wigle, M.D., Ph.D., research in the Thoracic Oncology Laboratory at Mayo Clinic is focused on thoracic oncology and lung organogenesis.

Thoracic oncology research

Dr. Wigle's Thoracic Oncology Lab has several basic and translational research interests in thoracic malignancies.

For example, the application of gene expression biomarkers for the molecular staging of non-small cell lung cancer (NSCLC) is an emerging field with the promise of clinical translation.

At a more basic research level, Dr. Wigle's research team is investigating the molecular steps transforming a normal bronchial epithelial cell through dysplasia to malignancy. The lab uses a number of modern genomic, proteomic and mouse transgenic technologies in these studies.

Lung organogenesis research

Understanding the molecular mechanisms involved in growth and development of the normal lung is fundamental to harnessing these processes for clinical tissue regeneration.

The lab, using a mouse model in this research, is studying the potential role of lung stem cells both as precursors of lung adenocarcinoma and for utilization in regenerative strategies.

About Dr. Wigle

Dr. Wigle, a thoracic surgeon at Mayo Clinic in Rochester, Minnesota, is a division chair and consultant in the Division of General Thoracic Surgery, a consultant in the Department of Physiology and Biomedical Engineering and an associate professor of surgery in the Mayo Clinic College of Medicine and Science.