Genetic studies of cognition and Alzheimer's disease risk
Genome-wide association studies of late-onset Alzheimer's disease have identified many risk variants. The lab has assessed the association of the top genome-wide association study variants and the apolipoprotein ε4 (APOE ε4) allele with memory progression to mild cognitive impairment or late-onset Alzheimer's disease.
For this study, participants evaluated at Mayo Clinic's campuses in Florida and Minnesota were analyzed. They were assessed for associations of genetic variants with memory decline, incident mild cognitive impairment and late-onset Alzheimer's disease. Each variant was tested individually and collectively using a single weighted risk score. The findings showed associations with several Alzheimer's disease genetic risk factors.
Our lab is analyzing the effect on cognition and cognitive decline using genetic risk factors and other multi-omic measures in a similar fashion.
Related publications
- Carrasquillo MM, Crook JE, Pedraza O, Thomas CS, Pankratz VS, Allen M, Nguyen T, Malphrus K, Ma L, Bisceglio G, Roberts RO, Lucas JA, Smith GE, Ivnik RJ, Machulda MM, Graff-Radford NR, Petersen RC, Younkin SG, Ertekin-Taner N. Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease. Neurobiology of Aging. 2015.
- Pedraza O, Allen M, Jennette K, Carrasquillo MM, Crook J, Serie D, Pankratz VS, Palusak R, Nguyen T, Malphrus K, Ma L, Bisceglio G, Roberts RO, Lucas JA, Ivnik RJ, Smith GE, Graff-Radford NR, Petersen RC, Younkin SG, Ertekin-Taner N. Evaluation of memory endophenotypes for association with CLU, CR1 and PICALM variants in black and white subjects. Alzheimer's & Dementia. 2014.