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Dr. Bu's lab is exploring the role of these receptors in regulating the metabolism of amyloid beta peptides as the initiator in the development of Alzheimer's disease.
The causes of synaptic loss and dementia in Alzheimer's disease are explored focusing on the molecular mechanism by which LRP6 regulates the development and how insulin resistance and glucose intolerance increases the risk of developing Alzheimer's disease.
Using cell culture techniques, the lab is studying the effects of ApoE isoforms on maintaining cerebrovascular homeostasis and the metabolism of amyloid beta.
Dr. Bu's lab is clarifying the role of AD — associated TREM2-R47H mutation and TREM2-mediated neuroinflammatory events in the neurodegenerative process.
Dr. Bu's lab is working with neuropathologists to analyze regional distributions of various AD-related molecules in human brain samples and how they correlate with neuropathological features.
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