Researcher examining DNA profiles.

Focus areas

The High-Dimensional Phenotyping Lab's research focuses on:

Cardiovascular physiology and electrophysiology

  • Artificial intelligence (AI)-based ECG screening.
  • Arrhythmia detection and risk prediction.
  • Leadless and untethered physiologic monitoring.
  • Biomarkers of cardiac recovery and functional capacity.

Autonomic disorders and postural orthostatic tachycardia syndrome

  • Wearable-driven diagnostic workflows.
  • Symptom-linked physiology mapping.
  • Predictive modeling integrating ECG, posture, impedance, motion and symptom reporting.

Human performance, sleep and recovery

  • Sensor-guided endurance markers.
  • Physiologic stress and resilience models.
  • Nocturnal autonomic patterning and PTSD-related sleep disruption projects.

Aging and longevity science

  • Development of Mayo's Proactive Solutions for PROlonging Resilience (PROSPR) Intrinsic Capacity Score.
  • Rolling-window physiologic aging models.
  • In-home assessments for frailty, cognition, vitality and stability.

Pain and neurophysiology

  • Novel digital pain biomarkers derived from ECG and multimodal physiology.
  • Early-stage, closed-loop physiologic pain modulation concepts.