Establishment and Characterization of New Preclinical Cell Models

Tumor tissues that are surgically removed can be used for much more than just diagnosis and drug screening. These samples can be processed into in vitro models for the creation of cell lines that mimic the properties of the original tumor tissue.

Once created, these immortalized cancer cell lines can serve as the foundation for new drug treatments, can help identify novel genes in cancer and can help contribute to a better understanding of certain subtypes of cancer.

The Cancer Biology and Translational Oncogenomics Laboratory of Dr. Copland has access to hundreds of patient tumor samples from which it is trying to establish cell lines.

The cell lines created in Dr. Copland's lab will adhere to a higher standard of validity, as the lab discovered that many established cell lines are actually cross-contaminated by another more-aggressive cell line.

Because of this discovery, the cell models that the Cancer Biology and Translational Oncogenomics Lab produces can be directly compared with and DNA fingerprinted to the original patient tissue.

In collaboration with clinicians around the country, Dr. Copland's lab can create validated cell models that will pave the way for better cancer treatment in the future.

Related presentations

Review poster presentations related to Dr. Copland's research on the characterization of new preclinical cell models (PDF files requiring Adobe Reader):