Levamisole and 5FU in Stage C colon cancer

The colon data set is used in D. Lin, Cox regression analysis of multivariate failure time data, the marginal approach, Statistics in Medicine 13:2233-2247, 1994. This data is not exactly the same as in Lin's paper -- we have more follow-up. One can get close to Lin's results by truncating follow-up on 15 Aug, 1989.

The Moertel paper discusses results from both stage B2 and stage C patients. This data file contains only the stage C results. Patients 1-929 are from the main trial, and the remainder from an older trial; Lin uses only the larger study.

• Patient number
• Study
  • 1 = Larger study (Moertel)
  • 2 = Historical study (Laurie)
• Treatment: 1=Observation, 2=Levamisole, 3=5-FU + Levamisole
• Sex: 0=female, 1=male
• Age
• Date of registration
• Obstruction: 0=No, 1=Yes
• Perforation: 0=No, 1=Yes
• Adherence: 0=No, 1=Yes
• Number of positive nodes
• Date of progression
• Progression status: 0=No, 1=Yes
• Date of last contact or death
• Last status: 0 = alive, 1=dead

The remaining variables are only available for study 1

• First stratification factor
  • 0 Treatment started 7-20 days post surgery
  • 1 Treatment started 21-35 days post surgery
• Second stratification factor
  • 0 1-4 lymph nodes involved
  • 1 more than 4 involved lymph nodes
• Third stratification factor, invasion of local organs: 0, 1, or 2
• Location of primary neoplasm
  • 1 Cecum
  • 2 Right Colon
  • 3 Hepatic flexure
  • 4 Transverse colon
  • 5 Splenic flexure
  • 6 Left colon
  • 7 Sigmoid colon
  • 8 Rectosigmoid
  • 9 Rectum
  • 10 Multiple sites
• Histologic type
  • 1 Adenocarcinoma
  • 2 Colloid(mucinous)
  • 3 Signet ring type
  • 4 Other
• Differentiation
  • 1 Well
  • 2 Moderate well (gr 2-3)
  • 3 Poor (grade 4)
• Extent of local spread
  • 1 Submucosa/not muscle
  • 2 Muscular/not serosa
  • 3 Serosa/not contiguous
  • 4 Contiguous structures
• Regional Implants: 0=No, 1=Yes
• Pre-operative CEA level (missing for many patients)
• Date of tumor resection
• Date of start of treatment