Obesity and Eating Disorders

This multidisciplinary research team at Mayo Clinic is involved in several clinical projects and National Institutes of Health-funded clinical trials that examine the influence of psychological functioning and neurobiology on eating disorders and obesity. Through these investigations, the goal is to improve long-term treatment outcomes.

Projects

  • Adult obesity. This research focuses on the impact of psychological factors on weight, weight-loss outcome following lifestyle, medication and procedural treatment, and weight regain following treatment.
  • Pediatric studies. This area focuses on understanding adolescents' preferences for social support in developing a healthy lifestyle and the effects of training children and their parents in stress management and mindful eating based on body mass index and cardiovascular risk markers.
  • Eating disorders. Several clinical projects and National Institutes of Health-funded clinical trials are examining the influence of psychological functioning and neurobiology on obesity and eating disorders and their treatment. Current adult investigations focus on primary care-based obesity treatment, liraglutide and intragastric balloon treatment of obesity, the effect of bariatric surgery versus calorie restriction on metabolism, the metabolome, the microbiome in people with type 2 diabetes, and predictors of gastric band removal versus revision.

    In addition, studies are undergoing to improve early identification and intervention of adolescent eating disorders, including developing a primary-care based model of adolescent eating disorder treatment designed to increase access to care and potentially improve patient outcomes.

Investigators

Grants

Investigator & Role Grant Title Funding Source Duration
Matthew M. Clark, Ph.D., L.P., Karen Grothe, Ph.D., L.P, co-principal investigators Effects of Liraglutide on Gastric Functions and their Relationship to Weight Loss in Obesity National Institute of Diabetes and Digestive and Kidney Diseases 09/2017-08/2021
Matthew M. Clark, Ph.D., L.P. co-investigator Healthy Immigrant Families: Working Together to Move More and To Eat Well National Heart, Lung, and Blood Institute 12/2011-11/2018
Karen Grothe, Ph.D., L.P., co-investigator A Randomized, Controlled, Multicenter Study Comparing the Spatz3 Adjustable Balloon System Plus Diet and Exercise to Diet and Exercise Alone Spatz FGIA Inc. 08/1/2016-07/31/2017
Bridget K. Biggs, Ph.D., L.P., Teresa B. Jensen, M.D., co-principal investigators Social Support and Motivators for Adolescent Weight Loss: Relations with Healthful and Unhealthful Weight Management Behavior Mayo Clinic Department of Family Medicine Small Grants Program, Mayo Clinic CCaTS grant number UL1TR000135 03/2017-02/ 2018
Florencia G. Que, M.D., principal investigator ReShape Lifesciences, Inc.: A Prospective, Randomized, Blinded, Parallel-Group, Multicenter Trial to Evaluate the Safety and Efficacy of the Maestro RC2 System in Treating Obesity EnteroMedics Inc. 05/2011-10/2016
Michael Camilleri, M.D., principal investigator Pharmacogenomics of Gastric Function and Weight in Obesity National Institute of Diabetes and Digestive and Kidney Diseases 09/2004-09/2015
Adrian Vella, M.D., principal investigator Adjustable Gastric Banding and Its Effects on Postprandial Glucose Metabolism Independent of Weight Loss National Institute of Diabetes and Digestive and Kidney Diseases 07/2010-06/2014
Leslie A. Sim, Ph.D., L.P., principal investigator An Evaluation of an Online, Family-Based Indicated Prevention Program for Adolescent Eating Disorders Mayo Clinic Department of Psychiatry and Psychology Small Grants Program 05/2012-05/2014