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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 15 for ALS - Amyotrophic lateral sclerosis

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  • Study status: Open/Status Unknown
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  1. A Study to Investigate the Safety and Pharmacokinetics of ABBV-CLS-7262 in Patients With Amyotrophic Lateral Sclerosis

    Jacksonville, FL, Rochester, MN

  2. A Study to Evaluate the Safety, Tolerability and Metabolism of BIIB105 in Subjects with Amyotrophic Lateral Sclerosis

    Jacksonville, FL

  3. A Trial to Evaluate the Efficacy and Safety of Reldesemtiv in Patients with Amyotrophic Lateral Sclerosis (ALS)

    Jacksonville, FL

  4. A Study to Evaluate Intrathecal Autologous Adipose-derived Mesenchymal Stromal Cells for Amyotrophic Lateral Sclerosis

    Rochester, MN, Scottsdale/Phoenix, AZ, Jacksonville, FL

  5. A Study to Evaluate MN-166 (Ibudilast) for 12 Months Followed by an Open-label Extension for 6 Months in Patients with Amyotrophic Lateral Sclerosis (ALS)

    Jacksonville, FL, Rochester, MN

  6. TJ-68 Clinical Trial in Patients with Amyotrophic Lateral Sclerosis (ALS) and Muscle Cramps

    Jacksonville, FL

  7. HEALEY ALS Platform Trial

    Jacksonville, FL, Rochester, MN

  8. A Study to Determine the Effectiveness and Safety of Oral Edaravone Administered in Subjects with Amyotrophic Lateral Sclerosis

    Jacksonville, FL, Rochester, MN

  9. A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTD

    Rochester, MN

  10. Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS)

    Jacksonville, FL

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