Vascular malformations

Displaying 7 studies

  • A Study of Bone Health in Patients with Overgrowth Syndromes Rochester, MN

    The goal of this study is to determine whether or not patients with overgrowth syndromes have decreased bone density.

  • A Study to Analyze Biopsy of Vascular Malformations Rochester, MN

    The purpose of this study is to validate a core biopsy technique for obtaining tissue from treatment naive vascular anomalies for clinical pathology and genomic analyses in patients undergoing clinically indicated sclerotherapy, embolization and/or ablation.

  • Pain Severity and Pain Interference Outcomes following Percutaneous MRI-Guided Laser Ablation and Cryoablation of Painful Peripheral, Soft Tissue Vascular Anomali Rochester, MN

    The purpose of this study is to determine if MRI-guided laser ablation and cryoablation result in significant improvements in both pain severity and pain interference measures at intermediate-term follow-up in patients with painful, soft-tissue vascular anomalies. The study will also test the hypothesis that immediate loss of intrinsic vascular anomaly T2 signal is an imaging biomarker to predict decreased pain and VA volume following MRI-guided laser ablation and cryoablation in patients with painful, soft-tissue vascular anomalies. 

  • A Study to Evaluate Topical VT30 to Treat Patients with Venous/Lymphatic Malformations Associated with PIK3CA or TEK Gene Mutations Rochester, MN

    The primary purpose of this two-part study is to evaluate the safety and tolerability of VT30.  

    Part 1 is a 4-week treatment, open-label, 4-sequence, escalating repeat-application cohort study, with intra-subject and inter-cohort dose escalation.

    Part 2 is a 12-week treatment, randomized, placebo-controlled, double-blind, safety and exploratory effectiveness study. Part 2 will be initiated only after the successful completion of Part 1 with results that demonstrate the general safety and tolerability of topically applied VT30. 

  • Human Blood and Tissues Repository for Neuroscience Research Jacksonville, FL

    The purpose of this study is to collect adult human blood, cerebrospinal fluid, brain, and spine tissues/fluids at time of surgery in order to conduct future studies of the cellular mechanisms of tissue invasion utilized by brain and spine tumors of the central nervous system (CNS).

  • Study of Health-related Quality of Life in Patients with Vascular Malformation-Overgrowth Syndromes Rochester, MN

    The purpose of this study is to use a validated survey tool to find health related quality of life scores for patients with vascular malformations or vascular malformation-overgrowth syndromes, to assess for potential differences in health related quality of life between patients with vascular malformation versus vascular malformation-overgrowth syndromes, as well as stratify across other variables including demographics and disease severity, and to compare health related quality of life in our patient population to that of the general population as well as to other well-studied chronic medical conditions.

  • A Study to Establish a Vascular Anomalies Tissue Repository Rochester, MN

    The purpose of this study is to develop a resource (bank) of biospecimens and data collected from individuals with a vascular tumor or malformation to facilitate discovery and development of novel biomarkers for diagnosis and treatment of disease, better elucidate etiologic factors relating to vascular anomalies, and novel targeted therapeutic strategies for vascular anomalies.


Mayo Clinic Footer