Clinical Trials

The purpose of this study is to investigate barriers and facilitators to PCN allergy de-labeling in primary care practice with qualitative methods. The purpose of the study is to understand patient experience with penicillin allergy and patients’ perspective on penicillin allergy delabeling.

Cephalosporin antibiotics are commonly used but can result in allergic reactions and anaphylaxis. There is no clear diagnostic approach for cephalosporin-allergic patients, and guidance for the use of other antibiotics in allergic patients is based on side chain chemical similarity and limited skin testing evidence. This project includes a clinical trial and mechanistic studies to optimize the approach to cephalosporin allergy and advance future diagnostics.