A Study Of Electroconvulsive Therapy In Right Unilateral
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 26-009100
About this study
The purpose of this study is to compare the degree of cognitive side effects (memory impairment, attention, and processing speed) between patients receiving RUL ECT versus BT ECT across the acute treatment course.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
Age 18 years or older
Referred for a course of ECT (RUL or BT) as part of standard clinical care by a Mayo Clinic psychiatrist
Primary psychiatric diagnosis of major depressive episode (unipolar or bipolar), treatment-resistant depression, or another condition for which ECT is clinically indicated
Able to provide written informed consent
Able to complete neuropsychological assessments in English or with an approved interpreter
Exclusion Criteria:
Age under 18 years
Pre-existing neurocognitive disorder (dementia, moderate-to-severe traumatic brain injury) that would confound cognitive assessment
Lack of capacity to provide informed consent at the time of enrollment
Active neurological condition that independently impairs cognition (e.g., active delirium, acute stroke within past 3 months)
Maintenance ECT (patients undergoing a continuation/maintenance ECT phase rather than an acute index course)
Inability to complete neuropsychological testing due to sensory or motor impairment
Note: Other protocol defined Inclusion/Exclusion Criteria may apply.
Eligibility last updated 008/03/2026. Questions regarding updates should be directed to the study team contact.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
More information
Publications
Publications are currently not available