Inclusion Criteria:

• Adults aged 60 years and older at the time of consent.

• Receiving primary care services at Mayo Clinic, residing in a site catchment area, with at least one primary care visit within the prior 3 years.

• Research authorization for use of medical records (Minnesota sites only).

• Provides written informed consent.

Exclusion Criteria: 

• Resides outside the catchment area served by the sites or receives primary care services at a non-Mayo facility.

• Declines specimen collection.

• Known cognitive impairment precluding consent or participation.

• Any condition that, in the opinion of the study PIs, would prevent safe completion of study requirementscollection.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 09/14/2026. Questions regarding updates should be directed to the study team contact.