Inclusion Criteria:

• Age ≥18 years.

• ≥10% burden of the target PVC on Holter monitoring <3 months prior to enrollment.

• Guideline-supported indication for first-time or redo catheter ablation of PVCs at the judgement of the electrophysiologist.

  • Enrollment of patients requiring a redo procedure will be capped at 30% of the planned enrollment (ie. n=18 patients) if the target PVC is the same or similar to the PVC targeted in the previous procedure(s).

• Patients with and without known structural heart disease will be eligible.

• Ability to undergo study-directed cardiac MRI pre- and post-procedure.

• Ability to undergo study-directed post-ablation coronary CT angiogram post-procedure.

• Ability to provide written informed consent.

Exclusion Criteria:

• LVEF <35%

• NYHA class IV

• History of sustained VT or VF

• Current or recent (<4 weeks) decompensated heart failure.

• Active systemic infection.

• Contraindication to LGE-MRI or contrast CT.

• Severe valvular disease requiring future intervention.

• Mechanical valve prosthesis.

• Pregnancy.

• Recent acute coronary syndrome (<6 months).

• Un-revascularized coronary artery disease.

• Presence of left ventricular assist device (LVAD) or transplanted heart.

• Presence of LV thrombus.

• Current use of inotropes.

• Recent stroke or TIA (<6 months).

• Presence of a systemic illness likely to limit survival to <1 year.

• Patient enrollment in other clinical study that could conflict with the current investigation.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 12/2/2025. Questions regarding updates should be directed to the study team contact.