Inclusion Criteria:

• English-speaking adults aged 32–48 years

• Have a uterus

• Have experienced a menstrual period in last 90 days

• Have a Mayo Clinic record number (MRN)

• Own or have regular access to an iPhone

• Symptomatic Cohort, participants must :

  • Have a documented diagnosis of uterine fibroids based on ultrasound or MRI imaging completed within the past 5 years.

  • Have a Pictorial Blood Loss Assessment Chart (PBLAC) score >100.

• Comparison Cohort, participants must:

  • Have no diagnosis of uterine fibroids, based on ultrasound or MRI imaging completed within the past 5 years

  • Have no abnormal uterine bleeding, defined as a PBLAC score <100

• Participants in both cohorts must be willing to:

  • Wear an Apple Watch continuously, during the day and night, for 3 months.

  • Share their Apple Watch data with a member of the study team via AirDrop to a Mayo Clinic secure MacBook device

  • Complete an in-person study visit in Rochester, Minnesota, at the end of the 3-month participation period

• Participants who require a study-provided Apple Watch must also:

  • Complete an in-person visit in Rochester, Minnesota, at the start of the 3-month participation period to receive and set up the temporary Apple Watch with a member of the study team

  • Complete an end-of-study in-person visit unless the study team receives Study App Template approval from Apple. If approval is obtained, the end-of-study in-person visit may not be necessary

Exclusion Criteria:

• Are not between the ages of 32-48 years old

• Do not have a uterus

• Do not regularly experience menstrual bleeding within the past 90 days

• Have a intrauterine device (IUD) or use birth control that prevents menstral bleeding

• Do not have a Mayo Clinic record number (MRN)

• Are unwilling to wear an Apple Watch or share Apple Watch data

• Do not own or have regular access to an iPhone

• Are pregnantat the time of enrollment

• Beecome pregnant during the study; such individuals witll be excluded or administratively withdraw

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 08/25/2026. Questions regarding updates should be directed to the study team contact.