Inclusion Criteria:

• Age ≥ 6 years of age

• Must have two of the following clinical history points:

  • Neonatal respiratory distress

  • Chronic nasal congestion/runny nose

  • Chronic cough

  • Situs/laterality defects

• Ability to provide informed consent and assent for minors when applicable

Exclusion Criteria:

• Recent history of sinus surgery or bloody nose in the past week

• Age < 6 years of age

• Inability to tolerate probe in nose

• Sinusitis or other respiratory exacerbation currently being treated with antibiotics

• Admitted to hospital for respiratory exacerbation (inpatient status)

• Inability to understand the requirements of the study or be unwilling to provide written informed consent (as evidenced by signature on an informed consent document approved by the IRB)

• Inability of parent/guardian to understand the requirements of the study, when applicable

• Any other reason for which the study investigators feel the patient is not a good candidate to complete the testing

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 10/21/2026. Questions regarding updates should be directed to the study team contact.