Inclusion Criteria:

• Age 18–75 years at the time of enrollment

• Confirmed diagnosis of breast or prostate cancer currently in remission, with no active cancer therapy at the time of enrollment

• Seen within the Mayo Clinic Comprehensive Cancer Center or cardio-oncology clinic within the last 12 months

• Able to perform a maximal cardiopulmonary exercise test on a stationary cycle ergometer or treadmill without physical contraindication

• Able to use a smartphone or tablet to access the Connected mHealth application

• Willing and able to provide written informed consent and HIPAA authorization

Exclusion Criteria: 

• Active cancer treatment of any kind at the time of enrollment, including chemotherapy, radiation, immunotherapy, or targeted therapy

• Physical limitation precluding safe participation in maximal exercise testing or a structured home exercise program

• Unstable cardiovascular condition that would constitute an absolute contraindication to exercise testing per current ACSM guidelines (e.g., unstable angina, decompensated heart failure, uncontrolled arrhythmia)

• No prior history of malignancy

• Not seen at the cardio-oncology or oncology clinic within the last 12 months

• Inability to communicate in English at a level sufficient to complete study surveys and exercise instruction

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 07/29/2026. Questions regarding updates should be directed to the study team contact.