A Study Of Comprehensive Genicular Nerve Radiofrequency Ablation For Refractory Knee Pain Using A Dual-Tined Electrode
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Jacksonville, Florida: 26-011276
About this study
The purpose of this study is to evaluate the effectiveness of a comprehensive genicular nerve RFA targeting technique in reducing knee pain
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
Age ≥ 18 years
Chronic knee pain (duration ≥ 6 months) in the index knee
Numerical Rating Scale (NRS) pain score ≥ 4/10 for the index knee
Failure to achieve adequate pain relief with conservative treatments
Positive response to diagnostic genicular nerve block with 0.5% bupivacaine (defined as ≥50% pain reduction lasting at least 3 hours)
Ability to understand study procedures and comply with them for the length of the study
Exclusion Criteria:
Significant psychiatric or cognitive disorder that may interfere with study participation or outcome assessment
Use of other investigational drugs or devices within 30 days prior to study entry
Current participation in another clinical trial related to knee pain treatment
Current drug or alcohol use or dependence that, in the opinion of the investigator, would interfere with adherence to study requirements
Inability or unwillingness of individual or legal guardian/representative to provide written informed consent
Ongoing litigation related to the knee pain or workers' compensation claims
Life expectancy less than 12 months due to any cause
Any other condition or circumstance that, in the opinion of the investigator, would make the patient unsuitable for participation in the study or unable to comply with follow-up requirements
Note: Other protocol defined Inclusion/Exclusion Criteria may apply.
Eligibility last updated 09/17/2026. Questions regarding updates should be directed to the study team contact.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Jacksonville, Fla.
Mayo Clinic principal investigator Christine Hunt, D.O. |
Open for enrollment |
|
More information
Publications
Publications are currently not available