A Study Of Semaglutide On Body Composition In Adolescents And Young Adults With Obesity

Overview

About this study

The purpose of this study is to evaluate changes in body composition including fat mass and lean mass during treatment with semaglutide in adolescents and young adults with obesity. To evaluate changes in body composition following semaglutide discontinuation.

Hypothesis: Discontinuation of semaglutide is associated with regain of fat mass but not muscle mass.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age 10 to 21 years.

  • BMI ≥ 95th percentile for age and sex prior to initiation of the weight loss medication

Exclusion Criteria:

  • Concurrent use of medication associated with weight gain and impact on body composition such as systemic steroids.

  • Initiation of a medication or change in the dose of medication associated with weight loss such as methylphenidate during the duration of follow-up.

  • Presence of an endocrine/hypothalamic disorder that can cause weight gain such as Cushing syndrome, untreated hypothyroidism, untreated growth hormone deficiency, pseudohypoparathyroidism type 1a.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 11/14/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Seema Kumar, M.D.

Open for enrollment

Contact information:

Seema Kumar

kumar.seema@mayo.edu

More information

Publications

Publications are currently not available