A Study Of Exercise Intolerance In Heart Failure With Preserved Ejection Fraction

Overview

About this study

The purpose of this study is to characterize maximal exercise capacity and central physiologic responses in HFpEF using integrated exercise testing by combining CPET, open circuit cardiac output measurements (OpCirc), flow mediated dilation (FMD), and near infrared spectroscopy (NIRS) into a single assessment and leveraged against clinically acquired echocardiographic (ECHO) data.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • >18 years old

  • Stable symptoms and severity of disease

  • Left ventricular ejection fraction ≥50%, and have

  • Diastolic dysfunction identified on ECHO

    • Diastolic dysfunction (E/e’) is defined as having an left ventricular filling pressure >15, or between 8-15 in combination with NTproBNP>220 ng/L or atrial fibrillation.

Exclusion Criteria:

  • Significant coronary artery disease

  • Inability to exercise

  • Poor blood pressure control

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 07/13/2026. Questions regarding updates should be directed to the study team contact.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

David Steidley, M.D.

Contact us for the latest status

More information

Publications

Publications are currently not available

Additional contact information

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