A Study Of Perioperative Antibiotic Prophylaxis With An Indwelling Catheter Prior To Holmium Laser Enucleation Of The Prostate

Overview

About this study

The purpose of the study is to compare the risk of infectious complications (UTI, pyelonephritis, sepsis, hospital admission, ED visits) for patients with an indwelling urinary catheter (urethral or suprapubic) or performing clean intermittent catheterization (CIC) receiving 3 or 7 days of peri-operative antibiotic prophylaxis at time of Holmium Laser Enucleation of the Prostate.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Candidate for HoLEP surgery

  • Indwelling urinary catheter or clean intermittent catheterization at the time of surgical listing

  • Must be 18 years or older.

  • The patient must be able to understand and willing to provide informed consent as described in this study protocol.

  • Patients without symptomatic UTI (culture with >100,000 CFU and symptoms) at the time of surgical intervention

Exclusion Criteria:

  • Under the age of 18 (Aims of study limited to adults; men begin to develop BPH around age 40)

  • Refuse to provide informed consent (Consent is required per regulations and guidelines to participate in study)

  • Anticipated need for perineal urethrostomy (Perineal urethrostomy increases the complexity of the surgery, increasing operative time and requiring prolonged catheterization which could confound UTI results.  Participants who require this are not a typical study patient).

  • History of multi-drug resistant organism on urine culture that is not susceptible to any oral agents (This study aims to compare participants who are able to receive oral prophylaxis Patients with multi-drug-resistant organisms require IV antibiotics and cannot be randomized to a 3 vs 7-day prophylaxis regimen.)

  • Symptomatic positive urine culture – standard of care is to treat these symptomatic positive urine culture (fever, chills, dysuria) with 7 days of therapy prior to surgery

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 06/02/2026. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Kevin Wymer, M.D.

Open for enrollment

Contact information:

Kevin Wymer

wymer.kevin@mayo.edu

More information

Publications

Publications are currently not available