A Study Of Amyloid PET In Normal Pressure Hydrocephalus

Overview

About this study

The purpose of this study is to determine how well CSF pTau181/Ab42 ratio and plasma pTau 217 correlates with the amyloid PET centaloid measure.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Male or female individuals who are 50 years of age or older.

  • Patients who have completed the neurological evaluation in the NPH clinic or Department of Neurology, and the clinician deem that the subject is eligible for enrollment (i.e., meeting NPH criteria).

 

Exclusion Criteria: 

  • Patients unable to lie down without moving for 20 minutes.

  • Claustrophobic patients unable to tolerate the scans.

  • Contradictions to MRI such as inability to fit inside the MRI scanner, metallic foreign bodies, pacemaker and other electronic devices, since the quantitative PET data analysis is based on anatomic criteria that are established uniquely for each subject by registration to his/her MRI

  • Individuals that are pregnant or cannot stop breastfeeding for 24 hours after the PET scan

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 10/29/2026. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Neill Graff Radford, M.D.

Contact us for the latest status

Contact information:

Neill Graff Radford

9049536869

graffradford.neill@mayo.edu

More information

Publications

Publications are currently not available