A Study Of Lactulose Mechanism Of Action

Overview

About this study

The purpose of this study is to compare the effect of stool from lactulose responders and non-responders in culture and animal experiments to understand lactulose’s mechanism of action.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Diagnosis of cirrhosis based on imaging, biopsy, or elastography

  • Prescribed lactulose for the first time in 3 months (could have been previously prescribed lactulose)

 

Exclusion Criteria: 

  • In the last month: rifaximin, antibiotics, immunosuppression, alcohol use (> 1 alcoholic beverage / week), other laxatives

  • Any prior bowel resection

  • Pregnant or breastfeeding

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 04/22/2026. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Patricia Bloom, M.D.

Open for enrollment

More information

Publications

Publications are currently not available

Additional contact information

Non-cancer trials contact form

Phone: 800-664-4542 (toll-free)

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