Inclusion Criteria:

• Clinical diagnosis of interstitial lung disease

• Radiologic lung abnormalities on diagnostic CT chest

• Anatomic imaging (clinical diagnostic CT chest) obtained within ≤ 90[KD1] [LK2]  days of consent

• Age ≥ 18 years

• Willingness and ability to provide informed consent

Exclusion Criteria:

• Pregnant as determined by a pregnancy test as per institutional guidelines for individuals of child-bearing potential

• Declining to use effective contraceptive methods during the study (for individuals of child-producing potential)

• Need for emergent surgery that would be delayed by participation

• Bacterial, viral, or fungal infections requiring systemic therapy

• Serious co-morbidities and serious nonmalignant disease (e.g., hydronephrosis, kidney failure, liver failure, or other conditions) that in the opinion of the investigator, physician of record and/or Sofie could compromise patient safety and/or protocol objectives.

• No available chest CT radiological data[KD1] [LK2] 

• No clear diagnosis of ILD

• Intolerability to perform the exam due to exuberant dyspnea or severely low pulmonary capacity.

• Breastfeeding. Note: nursing parents are allowed if the potential participant commits to pumping breast milk and discarding it from injection to ≥ 24 hours from the time of the [68Ga]FAPI-46 injection.

• Known hypersensitivity to any excipients used in [68Ga]FAPI-46

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 008/18/2025. Questions regarding updates should be directed to the study team contact.