A Study Of Noninvasive Metric To Measure Small Bowel Sensation
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 25-013906
About this study
The purpose of this study is to identify the concentration of hyperosmolar mannitol solution that will generate a range of symptoms in individuals without DGBI to establish the normative range of responses to SB distension.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
Age between 18-75
No current gastrointestinal symptoms and no prior history of GI disorders, in particular DGBIs
Standard inclusion criteria will include: ability to provide informed consent, participate in study procedures, absence of other diseases (structural or metabolic) which could interfere with interpretation of the study results, for females, must not be pregnant or lactating due to radiation exposure.
Stable doses of thyroid replacement, estrogen replacement, low-dose aspirin for cardioprotection, and birth control are permissible.
Exclusion Criteria:
Subjects on any medications that impact transit or integrity of small bowel mucosal barrier (e.g. chronic NSAIDS) of the GI tract will be excluded.
Patients with prior bowel surgery (not including appendectomy and cholecystectomy)
Patients who may have altered sensation (central sensitization or conditions that may induce bowel hyperalgesia) based on PI review of medical history (ie, fibromyalgia, endometriosis, chronic pelvic pain)
Note: Other protocol defined Inclusion/Exclusion Criteria may apply.
Eligibility last updated 02/17/2026. Questions regarding updates should be directed to the study team contact.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Rochester, Minn.
Mayo Clinic principal investigator Xiao Jing Wang, M.D. |
Contact us for the latest status |
|
More information
Publications
Publications are currently not available