A Study Of Impact Of Menopause On Blood Pressure Control During Submaximal Exercise
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 26-004569
About this study
The purpose of this study is to determine the impact of locomotor muscle afferent feedback on blood pressure during submaximal exercise in post-menopausal women,
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
≥18 years of age
Non-surgically induced menopause (for all post-menopausal women only)
No history of chronic cardiovascular, autonomic, and/or musculoskeletal diseases
Body mass index between 18 and 35 kg/m2
Able to engage in exercise
Exclusion Criteria:
<18 years of age
Sustained ventricular tachycardia and/or ventricular fibrillation within 21 days of visit 1
Second or third degree heart block
History of spinal stenosis, lumbar radiculopathy, or peripheral neuropathy
Allergy to fentanyl
Allergy to lidocaine
Surgical menopause
Body mass index <18 or >35 kg/m2
Current smokers and/or smoking history of >30 years
Pregnant women (testing will be done by CRTU if requested)
History of iodide allergy
Alanine transaminase and/or aspartate transaminase greater than 2 times the upper limit of normal (via clinical record within the past 6 months)
Creatinine value greater than or equal to 1.3 mg/dL (via clinical record within the past 6 months)
History of chronic cardiovascular, autonomic, and/or musculoskeletal diseases,
History of gastrointestinal obstruction
History of respiratory depression
History of opioid non-tolerance
Acute pain
Current treatment of exercise induced asthma
History of esophageal disorders
Current anticoagulation medication therapy use
Individuals who are not able to engage in exercise
Note: Other protocol defined Inclusion/Exclusion Criteria may apply.
Eligibility last updated 07/06/2026. Questions regarding updates should be directed to the study team contact.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Rochester, Minn.
Mayo Clinic principal investigator Joshua Smith, Ph.D., M.S. |
Contact us for the latest status |
|
More information
Publications
Publications are currently not available