A Study Of Cough Severity And Lung Function In Interstitial Lung Disease
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 26-001194
About this study
The purpose of this study is to characterize the experience of chronic cough in interstitial lung disease by using established chronic cough patient reported outcome measures and objective cough monitoring.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
Age greater than 18 and able to provide consent.
Diagnosis of fibrotic interstitial lung disease defined by the presence of greater than 10% fibrotic changes on CT imaging within 6 months of study enrollment.
Cough lasting greater than 3 months at the time of study enrollment.
Any disease severity based on pulmonary function testing.
Any treatment approach includes steroids, immune modulators, and antifibrotic agents.
Patient may be enrolled in other research studies
Exclusion Criteria:
Patients without research authorization,
Patients <18 years of age
Patients with acute respiratory tract infection
Patients with asthma or COPD exacerbation at the visit
Pregnant or lactating women
Active smokers using cigarettes, vaping, electronic cigarettes, cannabis within the last 2 weeks
Patients on use of angiotensin converting enzyme inhibitors
Patients with bronchiectasis
Patients with lung cancer
History of cognitive decline
History of aspiration/ aspiration pneumonia
History of dysphagia
Acute congestive heart failure exacerbation
History of mitral stenosis
Patients in their end of life care
Less than 10% fibrosis on CT imaging
Cough lasting less than 3 months at the time of study enrollment.
Cognitive or memory impairment with inability to complete questionnaires.
Patients unwilling to wear actigraph and or cough monitor for 7 days.
Note: Other protocol defined Inclusion/Exclusion Criteria may apply.
Eligibility last updated 03/03/2026. Questions regarding updates should be directed to the study team contact.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Rochester, Minn.
Mayo Clinic principal investigator Vivek Iyer, M.D., M.P.H. |
Contact us for the latest status |
|
More information
Publications
Publications are currently not available