A Study Of Cough Severity And Lung Function In Interstitial Lung Disease

Overview

About this study

The purpose of this study is to characterize the experience of chronic cough in interstitial lung disease by using established chronic cough patient reported outcome measures and objective cough monitoring.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age greater than 18 and able to provide consent.

  • Diagnosis of fibrotic interstitial lung disease defined by the presence of greater than 10% fibrotic changes on CT imaging within 6 months of study enrollment.

  • Cough lasting greater than 3 months at the time of study enrollment.

  • Any disease severity based on pulmonary function testing.

  • Any treatment approach includes steroids, immune modulators, and antifibrotic agents.

  • Patient may be enrolled in other research studies

Exclusion Criteria:

  • Patients without research authorization,

  • Patients <18 years of age

  • Patients with acute respiratory tract infection

  • Patients with asthma or COPD exacerbation at the visit

  • Pregnant or lactating women

  • Active smokers using cigarettes, vaping, electronic cigarettes, cannabis within the last 2 weeks

  • Patients on use of angiotensin converting enzyme inhibitors

  • Patients with bronchiectasis

  • Patients with lung cancer

  • History of cognitive decline

  • History of aspiration/ aspiration pneumonia

  • History of dysphagia

  • Acute congestive heart failure exacerbation

  • History of mitral stenosis

  • Patients in their end of life care

  • Less than 10% fibrosis on CT imaging

  • Cough lasting less than 3 months at the time of study enrollment.

  • Cognitive or memory impairment with inability to complete questionnaires.

  • Patients unwilling to wear actigraph and or cough monitor for 7 days.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

 Eligibility last updated 03/03/2026. Questions regarding updates should be directed to the study team contact.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Vivek Iyer, M.D., M.P.H.

Contact us for the latest status

More information

Publications

Publications are currently not available

Additional contact information

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Phone: 800-664-4542 (toll-free)

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