Inclusion Criteria:

• Adult patients (≥18 years old).

• Patients admitted to the Intensive Care Unit (ICU) requiring continuous physiological monitoring.

• Patients receiving invasive mechanical ventilation for at least 24 hours (mandatory for ventilator waveform collection).

• Ventilated patients on controlled or assisted ventilation modes (e.g., volume control, pressure control, pressure support, adaptive modes).

• Patients connected to Philips patient monitoring systems capable of recording ECG, arterial pressure, central venous pressure (CVP), and SpO₂ waveforms.

• Patients with invasive arterial blood pressure (A-line) and/or CVP monitoring, if available.

• Patients with an anticipated ICU stay of ≥24 hours, ensuring sufficient data collection.

• Patients connected to mechanical ventilators with an RS-232 port for waveform extraction.

• Patients on ICU monitors capable of continuous waveform recording and storage.

Exclusion Criteria:

• Patients will be excluded from the study if they meet any of the following criteria:

• Age & Non-ICU Patients

• Patients under 18 years of age

• Patients not admitted to the ICU (e.g., general ward, emergency department, or step-down units)

• Non-Ventilated Patients

• Patients who are not receiving invasive mechanical ventilation

• Patients on non-invasive ventilation (NIV), high-flow nasal cannula (HFNC), or supplemental oxygen alone

• Short ICU Stay or Early Discontinuation

• Patients expected to be in the ICU for less than 24 hours

• Patients anticipated to be extubated or weaned from mechanical ventilation within 24 hours

• Inadequate Data Collection

• Patients on ventilators without an RS-232 port, preventing waveform extraction

• Patients on ICU monitors incapable of continuous waveform recording

• Incomplete or corrupted waveform data that cannot be analyzed

• Do-Not-Resuscitate / Do-Not-Intubate Orders

• Patients with DNR or DNI orders at the time of ICU admission

• Neuromuscular Disorders Affecting Respiratory Effort

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 12/31/2025. Questions regarding updates should be directed to the study team contact.