Usefulness of Ultrasound Lung Comets as a Sign of Interstitial Pulmonary Edema in Patients with Subarachnoid Hemorrhage Receiving Fluid Resuscitation

Overview

About this study

The purpose of this study is to compare the appearance of lung ultrasound imaging (described as “lung comet”) in addition to decreased inferior vena cava diameter (IVCD) respiratory variation with CXR film and chest CT as signs to detect interstitial pulmonary edema in patients with high-grade subarachnoid hemorrhag.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  1. Patients aged 18-85 years of age, regardless of gender, ethnicity or background
  2. Patients with aneurysmal subarachnoid hemorrhage (Fisher grade 2 or higher) verified by CT brain imaging and either CT angiogram or formal cerebral angiogram with documented intracranial aneurysm
  3. Able to be enrolled within 72 hours of hospital admission
  4. Patients that will have daily chest x-rays per standard of care

Exclusion Criteria: 

  1. Patients or their medical surrogate refuse written consent or enrollment in study
  2. Patients with medical history of pleuritis, bronchiectasis, or severe chronic obstructive pulmonary disease (history of hospitalization or intubation due to COPD in the last 5 years, current daily use of B2 agonist inhalers/nebulizer for COPD, long term use of steroids for COPD in the last year, very day or night dyspnea due to COPD.
  3. Flail chest (new fractures that lead to acute respiratory failure and need for mechanical ventilation)
  4. Extubated patients prior to enrollment to the study

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Jose Diaz-Gomez

Closed for enrollment

Contact information:

Dale Gamble

Gamble.Dale@mayo.edu

More information

Publications

Publications are currently not available