Inclusion Criteria:

To be eligible for inclusion in this study, the subjects must meet any of the following criteria:

• Subjects, 18 years and older, undergoing routine orthopedic surgical procedures that will have already have IV placement as part of the surgical procedure.

• Complete a signed consent form.

Exclusion Criteria: 

To be eligible for inclusion in this study, the subjects must not meet any of the following criteria:

• History of superficial infection within 6 months of study enrollment, or  evidence of current superficial infection.

• Taking anticoagulant medications (e.g. warfarin, heparin) or clopidogrel (Plavix).

• Taking anti-rheumatic disease medication (including methotrexate or other antimetabolites) within 3 months prior to study enrollment.

• On chronic, immunosuppressive transplant therapy or having a chronic, immunosuppressive state, including use of systemic steroids/corticosteroids.

• Systemicinflammatory,rheumatologicalorconnectivetissuedisorderincludingbutnot limited to rheumatoid arthritis, systemic sclerosis, system lupus erythematosus, and Ehlers-Danlos Syndrome.

• Ongoing infectious disease, including but not limited to tuberculosis, HIV, hepatitis, and syphilis.

• History of cancer/malignancy with the exception of adequately treated basal cell or squamous cell carcinoma of the skin within the last 5 years.

• History of blood dyscrasia, including but not limited to anemia, thrombocytopenia, and monoclonal gammopathy.

• Currently pregnant individuals.

• Individuals under the age of 18 years old.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 10/24/2025. Questions regarding updates should be directed to the study team contact.