Inclusion Criteria:

• Adult males or females (age ≥ 18 years)

• A history of chronic low back for at least 3 months. (Measured by patient history and physical exam)

• A palpable taut band or nodule within the skeletal muscle

• Hypersensitive tender spot within the taut band

• Recognition of current pain complaint by pressure on the tender nodule/taut band

• Painful limit to the full stretch range of motion

Exclusion Criteria:

• Pregnancy or breastfeeding

• Any contraindication to an MRI exam, or severe claustrophobia that would prevent safe completion of the scan

• Previous therapy in the area to be treated within 3 months

• Previous severe back injury (including fracture) or surgery

• Any neurological conditions or active systemic disease (e.g. diabetes, peripheral vascular disease, cancer, rheumatoid arthritis) that impaired sensation/pain perception

• Severe osteoarthritis

• Skin injuries in the area to be treated

• Known or suspected clinically significant lumbar disc or other structural spinal pathology considered to be the primary cause of the participant’s symptoms or makes study participation or manual therapy inappropriate.

• Have a known history of any condition or factor judged by the investigators to preclude participation in the study or which might hinder adherence

• Inability to provide consent

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 08/04/2026. Questions regarding updates should be directed to the study team contact.