AI-Guided LBBAP

Overview

About this study

The purpose of this study is to compare the effectiveness of AI-guided LBBAP versus conventional LBBAP (not AI-guided) in improving CRT response rates and clinical outcomes.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age: 18 years or older.

  • Left Ventricular Ejection Fraction (LVEF): <50% within 6 months prior to enrollment.

  • QRS Duration: Resting QRS duration ≥ 130 ms on ECG OR anticipated right ventricular pacing > 40% OR device in place with right ventricular pacing > 40%.

  • Medical Therapy: Optimized on guideline-directed medical therapy for heart failure.

  • AI-ECG probability of low LVEF: >0.5.

All subjects enrolled in this study will be capable of providing informed consent or will have an appropriately legally authorized representative available to do so on their behalf.

Exclusion Criteria:

  • Age less than 18 years old.

  • Inability to follow-up.

  • Pregnancy

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 7/10/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Fatima Ezzeddine

Open for enrollment

Contact information:

CVRU Heart Rhythm Services Research Team

(507) 255-0774

More information

Publications

Publications are currently not available