Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
Greater than 21 years old
American Spinal Injury Association Impairment Scale A-D, to encompass a representational spectrum of autonomic dysfunction after spinal cord injury
A diagnosis or history of chronic lower body pain
Neurological level of injury above T10, as defined by the International Standards for Neurological Classification of Spinal Cord Injury. Incorporating level of injury over this broad range to capture the spectrum of autonomic dysfunction. Individuals with injuries below T10 will not be included to ensure transcutaneous spinal cord stimulation does not occur over the injury/glial scar, where it may have altered properties.
Time since injury of greater than six months, given early changes in spinal cord connectivity and recovery prior to this.
Both individuals with and without currently implanted epidural spinal cord stimulators will be enrolled
Exclusion Criteria:
Severe cardiopulmonary dysfunction
Untreated active depression
Frequent hypotension or uncontrolled hypertension
Significant cognitive impairment
Positive pregnancy test
Enrollment in another interventional clinical trial
Incarceration or pending legal action
Any condition that may compromise protocol adherence, patient safety, or data validity
Note: Other protocol defined Inclusion/Exclusion Criteria may apply.
Eligibility last updated 008/11/2025. Questions regarding updates should be directed to the study team contact.