The CORRECT Trial

Overview

About this study

The purpose of this study is to compare the effectiveness of two commonly used buffer agents to treat metabolic acidosis in patients following cardiac surgery, sodium bicarbonate and THAM. Patients undergoing cardiac surgery requiring cardiopulmonary bypass who arrive to the ICU with a metabolic acidosis will be randomized to receive one of the two buffer agents. Currently, it is unknown which buffer agent is more effective and use is determined by clinician preference and impression of availability. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Cardiothoracic surgery with use of cardiopulmonary bypass.
  • Presence of metabolic acidosis (defined as a base excess of <-5)
  • Age ≥ 21 years.

Exclusion Criteria

  • Non-cardiac surgery patients or cardiac surgery without cardiopulmonary bypass.
  • Absence of metabolic acidosis (defined as a base excess of <-5)
  • Pregnant patients.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 2/19/2025. Questions regarding updates should be directed to the study team contact.
 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Misty Radosevich, M.D.

Contact us for the latest status

Contact information:

Misty Radosevich M.D.

(866) 265-9263

radosevich.misty@mayo.edu

More information

Publications

Publications are currently not available