A Study Of Vocal Biomarkers Of Disease Flares In IBD

Overview

About this study

The purpose of this study is to identify and evaluate a vocal signal capable of distinguishing active IBD flares from remission in patients with ulcerative colitis or Crohn’s disease using machine learning analysis of short voice recordings and to determine whether specific vocal patterns predict response versus non-response to medical therapy in this population.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age 16–80 years

  • Hospital admission for a confirmed flare of UC or Crohn’s disease (endoscopic or imaging evidence plus elevated inflammatory markers)

  • Fluent in English

  • Ability to provide informed consent

  • Willingness to record voice three times daily during hospitalization and again one month post-discharge

Exclusion Criteria:

  • Current upper respiratory tract infection

  • History of significant speech or voice disorder unrelated to IBD (e.g., vocal fold paralysis)

  • Current use of voice-modifying treatments (e.g., recent laryngeal surgery, vocal fold injections)

  • Inability to use a smartphone or recording device reliably during hospitalization or follow-up period

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

 

Eligibility last updated 07/07/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Francis Farraye, M.D., M.S.

Open for enrollment

Contact information:

Bradley Weisman

weisman.bradley@mayo.edu

More information

Publications

Publications are currently not available