Radiotherapy compared to Corticosteroid Injection for Treatment of Hand Osteoarthritis

Overview

About this study

To evaluate the efficacy of low-dose radiation therapy (LDRT) compared to corticosteroid injection (CSI) therapy for reducing pain from hand osteoarthritis.

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patient at Mayo Clinic, Rochester, MN.
  • Age 50 years or older.
  • ModerateSevere (Kellgren-Lawrence grade 3-4) hand OA on hand radiographs within the last 24 months[SM1] [EM2] 
  • Hand OA pain with a minimum VAS score relating to hand pain of 4 when using the affected hand.

Exclusion Criteria:

  • History of previous surgery to the affected hand(s).
  • Autoimmune joint disease such as rheumatoid arthritis or psoriatic arthritis.
  • Posttraumatic hand pain.
  • Acute crystalline arthritis (gout or pseudogout) flare.
  • Active use of opioid pain medication(s) within the last 3 months.
  • Fibromyalgia or central sensitization syndrome.
  • Hand CSI within the past 3 months.
  • History of hand LDRT within the past 3 months.
  • Inability to complete study questionnaires.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 1/31/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Terin Sytsma, M.D.

Contact us for the latest status

Contact information:

Jennifer Manggaard CCRP

Manggaard.Jennifer@mayo.edu

More information

Publications

Publications are currently not available