Impact Of RFA On Esophageal Distensibility And Mucosal Impedance

Overview

About this study

The purpose of this study is to determine the change in distensibility as measured by functional luminal impedance planimetry (FLIP) as well as the change in mucosal impedance in the esophagus in dysplastic Barrett’s esophagus patients receiving radiofrequency ablation

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Male or female ≥ 18 years of age.

  • Confirmed histologic diagnosis of BE with dysplasia or intramucosal carcinoma (IMCa)

  • Ability to take high-dose PPI therapy (such as omeprazole 40 mg BID)

  • Willing to undergo multiple rounds of EET for management of BE (which is the guideline clinical recommendation for management of this disease(4)

Exclusion Criteria:

  • History of esophageal ablation.

  • History of esophageal stricture.

  • History of esophageal or gastric surgery.

  • Pregnancy

  • History of achalasia

  • History of delayed gastric emptying confirmed by 4-hour gastric emptying study.

  • Receipt of glucagon-like peptide-1 agonists.

  • Adults lacking the capacity to consent for self.

  • Lack of English fluency.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 5/13/2025. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Don Codipilly, M.D.

Contact us for the latest status

Contact information:

Taylor Hines

(507) 538-9959

Hines.Taylor@mayo.edu

More information

Publications

Publications are currently not available