Fermented Diet on Microbiome Diversity in Long COVID

Overview

About this study

The purpose of this study is to evaluate the effects of fermented foods on bacterial gut microbiome diversity of long-COVID subjects.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adult (> 18 years old)
  • Patients who have long COVID symptoms
  • Long COVID will be defined as:
  • A previously documented COVID + infection
  • A presence of neurological symptoms that started following COVID infection (fatigue, difficulty concentrating, depression, anxiety) as per CDC definition of Long Covid (16).
  • Own a smart device capable of downloading a food logging application. Able to understand and document informed consent
  • Seen in the Mayo Clinic long-COVID Clinic within the Department of General Internal Medicine

Exclusion Criteria:

  • History of dementia, moderate or severe cognitive dysfunction, developmental delay, psychotic disorders such as schizophrenia
  • Unable to tolerate oral foods
  • Potential contraindications to a fermented food diet (including chronically immunosuppressed including organ transplant recipients)
  • Neutropenic as listed in the “active problems” list in the EMR
  • Undergoing chemotherapy at the time of consent
  • Taking MAOIs at the time of consent.
  • Active uncontrolled inflammatory bowel disease including ulcerative colitis, Crohn’s disease, indeterminate colitis, irritable bowel syndrome (moderate or severe), infectious gastroenteritis, colitis or gastritis, Clostridium difficile infection (recurrent), malabsorptive diseases (such as Celiac disease), major surgery of the GI tract with the exception of cholecystectomy and/or appendectomy in the past 5 years, or any major bowel resection at any time.
  • A reported consumption of 2 servings of probiotic fermented food per day in their normal baseline diet.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 10/17/2024. Questions regarding updates should be directed to the study team contact.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Lioudmila Karnatovskaia, M.D.

Open for enrollment

Contact information:

Benjamin Harris M.D.

(507) 284-2964

Harris.Benjamin@mayo.edu

More information

Publications

Publications are currently not available