Inclusion Criteria

• Demographic characteristics: ≥ 18 and < 70 years of age.
• Health status: any schizophrenia spectrum disorder as defined by the DSM5 for case group; psychiatric control group can have any DSM-5 defined Bipolar, Depressive, or Anxiety Disorders; healthy controls have no psychiatric illness as defined by DSM-5.
• Ability to understand risks of blood draw.

Exclusion Criteria

All candidates meeting any of the exclusion criteria will be excluded from study participation:

• Demographic characteristics: < 18 or ≥ 70 years of age.
• Use of rituximab or other similar medications that cause lymphocyte cell death in the past 6 months.
• Inability or unwillingness of individual to give written informed consent.
• Fever, chills, or other objective evidence of ongoing infection at a time of the blood draw.

Special Subpopulations

• Individuals with legal guardians can participate in the study, as long as both participant and guardian both agree to participation. Guardian will sign the consent form.
• Currently involuntary hospitalized patients will not be recruited and will be excluded from this study.
• We anticipate adequate recruitment of racial and other minorities, based on past recruitment experience with similar patient population (e.g. 29% of participants in IRB#21011143 were African American).

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 1/23/2025. Questions regarding updates should be directed to the study team contact.